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Energy metabolism at whole-body, cellular, and even organelle, i.e., mitochondrial, levels requires adequate regulation in order to maintain or improve (metabolic) health. In eukaryotic cells, mitochondria are key players in energy (ATP) production via oxidative phosphorylation. Both macro- and micronutrients potentially influence energy metabolism and mitochondrial functioning, either as substrates for (oxidative) catabolism or as essential constituents of enzymes or protein complexes involved in (mitochondrial) energy metabolism. This book contains a valuable collection of empirical preclinical and human studies to assist in the development of understanding and progress this area of research on improving health and, more specifically, metabolic health.

Medicine --- insulin --- lipogenesis --- obesity --- glucose homeostasis --- adipocytes --- cortisol --- ketones --- s-IgA --- exercise --- low carbohydrate diet --- NAFLD --- omega-3 --- krill oil --- phospholipids --- high-fat diet --- C57BL/6N mice --- thermoneutral temperature --- iron deficiency --- striated skeletal muscle --- physical capacity --- fatigue --- mitochondrial metabolism --- complex I --- resting metabolic rate --- prediction equation --- ageing adults --- overweight --- adiposity-based chronic disease --- energy balance --- metabolism --- n/a

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Obesity and related co-morbidities are increasing worldwide and pose a serious health problem. Changes in lifestyle and diet would be the best remedies to fight obesity; however, many people will still rely on medical aid. Marine organisms have been prolific in the production of bioactive compounds for many diseases, e.g., cancer, and promise to be an excellent source for natural-derived molecules and novel nutraceuticals. Bioactive compounds with beneficial activities towards obesity have been described from diverse marine organism including marine algae, bacteria, sponges, fungi, crustaceans or fish. This Special Issue will highlight the progress in the following topics: Bioactive compounds for the treatment of obesity and obesity-related co-morbidities (diabetes, fatty liver, hyperlipidemia) from marine organisms; the isolation of novel compounds, the bioactivity screening of marine organisms and the elucidation of molecular mode of action of marine bioactive compounds.

natural compounds --- anti-obesity drugs --- high fat diet --- Ishige okamurae --- fat --- zebrafish Nile red fat metabolism assay --- physical exercise --- JAK2-STAT3 --- metabolite profiling --- obesity --- chlorophyll derivatives --- brown seaweed --- Skate skin --- PPAR? --- marine alga --- marine biodiscovery --- skate skin --- lipolytic --- leptin --- uncoupling protein 1 --- 3T3-L1 cells --- glucolipid metabolism disorder --- nutrition --- bioactivity --- chitosan oligosaccharide --- diphlorethohydroxycarmalol (DPHC) --- nutraceuticals --- whole small animal models --- high-fat diet --- adipocyte --- dyslipidemia --- bioactivity screening --- peroxisome proliferator-activated receptor gamma --- white adipose tissue --- antiobesity --- fatty liver disease --- thermal proteome profiling --- inflammation --- cyanobacteria --- Raja kenojei --- Arthrospira maxima --- cellularity --- adipocytes --- bioactive compound --- collagen peptide --- double-blind --- bisabolane-related compounds --- proliferation --- fatty acid metabolism --- cholesterol metabolism --- collagen --- randomized controlled trial --- mechanisms of action --- murine pre-adipocytes --- adipogenesis --- fucan --- marine sponges --- label-free quantitative proteomics --- diabetes --- body fat

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The present Special Issue summarizes the available scientific evidence concerning the nutrients and biomarkers in musculoskeletal diseases linked to the metabolic conditions secondary to COVID-19 confinement, osteoporosis prevention for patients with inflammatory bowel diseases, and the nutritional status in patients with spinal muscular atrophy. Furthermore, it explores the novel findings for experimental animal models of pharmacological agents to improve the regeneration of muscle tissue; acetylcholine spontaneous release located in the neuromuscular junction in mice, secondary to hypercaloric diet supplementation with an increase in spontaneous neurotransmission and the activation of myofascial trigger points associated with myofascial pain syndrome; and myogenic biomarkers in musculoskeletal conditions and gene expression associated with vitamin D and L-cysteine co-supplementation. This Special Issue is edited by a multidisciplinary group comprising the Universidad Complutense de Madrid, Universidad Rey Juan Carlos, Universidade da Coruña, and Universidad Europea de Madrid.

Humanities --- Social interaction --- COVID-19 --- acute sedentary lifestyle --- step reduction --- positive energy balance --- metabolic consequences --- insulin resistance --- metabolic syndrome --- sarcopenia --- bowel diseases --- diet --- osteoporosis --- bone density --- nutrients --- muscle unloading --- muscle reloading --- sirtuin-1 --- muscle progenitor cells --- activated satellite cells --- quiescent satellite cells --- muscle regeneration markers --- electromyography --- high-fat diet --- myofascial pain syndrome --- obesity --- spontaneous neurotransmission --- vitamin D deficiency --- l-cysteine --- glutathione --- myogenic markers --- dystrophy markers --- skeletal muscle --- spinal muscular atrophy --- metabolomics --- nutrition --- therapeutics --- biomarkers --- n/a

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The papers reported here will contribute to proposing new insights into the mechanisms of several conditions, as well as suggesting new diagnostic alternatives and therapeutic targets in widespread pathologies such inflammation and inflammatory-based diseases. The discovery of the new is, as always, anchored in recourse to the old.

toxicity --- long-lasting effect --- iso-?-acids --- ammonium glycyrrhizinate --- metabolomics --- cytokines --- Alnus sibirica --- energy metabolism --- curcumin --- antineuroinflammation --- nitric oxide --- antioxidant --- nutraceutical food --- liver --- nardochinoid B --- endometriosis --- adipose tissue --- Nardostachys chinensis --- tau --- macrophage --- nociception --- heme oxygenase-1 --- enzymatic hydrolysis --- IL-6 --- nuciferine --- docking --- chronic nonbacterial prostatitis --- black tea polyphenol --- network pharmacology --- Tagetes patula L. --- SEM --- lipopolysaccharide --- solid lipid nanoparticle --- tauopathy --- memory --- lupane-type triterpene --- acute lung injury --- inducible nitric oxide synthase --- inflammation --- anti-inflammatory --- microglia --- resveratrol --- theaflavins --- hirsutanonol --- short-term high-fat diet --- inflammatory disease --- juçara --- oregonin --- PPARs --- NF-?B --- neuroprotection --- Portulaca oleracea --- TNF-? --- depression

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It is known today that more than 61% of human pathogens are zoonotic, representing 75% of all emerging pathogens during the past decade, presenting an increasing a matter of concern, particularly in modern days where global warming keeps is causing climatic conditions conducive to the introduction of exotic infectious agents or disease vectors in new territories. This book compiles studies that approach a myriad of zoonotic infectious diseases and their complex mechanisms. This is a brief but in-depth collection that showcases the need to address health at the animal–human–environment interface, in a One Health perspective.

Medicine --- Epidemiology & medical statistics --- trefoil factor family member 2 (TFF2) --- inflammation --- tissue repair --- zoonotic disease --- Panthera leo --- human health --- biosecurity --- wildlife farming --- wildlife trade --- disease transmission --- BRSV --- cattle --- isolation --- respiratory disorders --- sequencing --- avian influenza --- homologous vaccine --- heterologous vaccine --- broiler --- early infection --- bovine papillomavirus --- Egypt --- nucleic acid lateral flow immunoassay --- PCR --- phylodynamic --- whole-genome sequencing (WGS) --- chicken --- antimicrobial resistance genes --- virulence genetic cluster --- schistosome --- Allobilharzia visceralis --- whooper swans --- obstructive phlebitis --- endosymbionts --- Hemolivia --- surveillance --- tortoises --- tick-borne pathogens --- ticks --- haemogregarines --- gamogony --- sporogony --- schizongony --- molecular analysis --- high-fat diet --- immunity --- damage --- mice --- Brazil --- HEV --- zoonotic --- One Health --- n/a